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KMID : 0370219750190040227
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Yakhak Hoeji
1975 Volume.19 No. 4 p.227 ~ p.233
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Stop-flow Analysis of the Diuretic Action of Guanethidine in the Dog
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고석태/Ko ST
김성원/김성오/Kim SW/Kim SO
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Abstract
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The diuretic action of guanethidine was investigated in the dogs by means of the stop-flow technique. Guanethidine increased the rejection of sodium in the ascending limb of Henle’’s loop, as wellas in the proximal and distal tubules, resulting in the decrease of the concentrating ability of the kidney, in marked natriuresis and diuresis. It was also effective during an osmotic diuresis, which was induced by in fusing 10% mannitol solution intravenously with a speed of 10ml/min. The drug can exhibit its effect even under the diuretic action of mercurophylline, suggesting a different mechanism from that of mercuric diuretics.
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